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Classical benzodiazepines (diazepam, alprazolam, phenazepam) bind directly to a specific allosteric site on the GABA-A receptor, producing potent anxiolysis alongside sedation, muscle relaxation, cognitive impairment, tolerance development, and physical dependence

We interpret that the type IIx/IIb cluster identified here represents a transitional state between types IIx and IIb because 39% of the cells in this cluster coexpress Myh1 and Myh4 and because this cluster does not differentially express markers of high metabolic activity ( Tnnc2 , Tnni2 , Mb , Cox6a2 , Cox6c , Atp5e , Atp5g1

Ketorolac also does not prevent increases in intraocular pressure or decreases in aqueous outflow induced by topical corticosteroids