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Interestingly, the mesenchymal shift by Day 45 suggests greater cellular complexity at later stages, potentially facilitating iHLO use in modeling liver pathologies such as fibrosis, cirrhosis, and liver remodeling, as indicated by increased expression of hepatic stellate cell markers such as DES and VIM 33,34

Watch for signs of an allergic reaction, such as hives, itching, swelling, or difficulty breathing, and seek immediate medical attention if they occur

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- IGF-1 (trial data suggests no meaningful change