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Decreased levels of H3K4me3 have also been identified at the upstream GAA repeat region, but not at the promoter region, which suggests a more pronounced defect of the post-initiation and elongation stages of FXN gene expression rather than an early transcription initiation defect (Punga and Buhler, 2010

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Aquaporins (AQPs), especially AQP9, are membrane proteins facilitating the transport of water, glycerol, and small solutes 8

In contrast, gsh2 mutants had no detectable extracellular GSH, consistent with the inability of these mutants to synthesize GSH endogenously (Fig