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Hormones or genetics are the main triggers for the patches of discoloration known as melasma

5 Conclusions/Outlook Even 200 years after the first description of PD, its pathophysiology is still far from being fully understood

on the contrary, the amount of the lipid peroxidation product malondialdehyde increased in the same tissue (Bosch-Morell et al., 2009, 2011) have confirmed significant increased levels of lipid peroxidation and marked decrease in GSH, superoxide dismutase and catalase activities in the sciatic nerve of rats which were given alcohol for 10 weeks

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