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MET overexpression was shown to trigger an increase of BRCP/ABCG2 and ABCB1/MDR1 expression in doxorubicin-resistant (DR) ovarian carcinoma cells [32] and in cisplatin-resistant NSCLC cell lines [31] respectively

111 Brain tumors represent a disease process in which the dynamic characteristics of the BBB present significant challenges for therapy

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