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The pathophysiological basis of diabetic cardiomyopathy development

Furthermore, quercetin induces M1 macrophage/microglia polarization towards M2 after SCI by inhibiting signal transducer and activator of transcription 1 and NF-B pathways (Fan et al., 2019), and also substantially reduces ROS production and inhibits NLRP3 inflammasome activation in SCI rats to promote neurological recovery (Jiang et al., 2016c)

This reveals that glutathione binds in the G site in a very similar fashion as the glutathione portion of substrate analogues in other structures and also that glutathione binding alone is sufficient to stabilize the C-terminal helix of the protein