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In this sense, prior works have related menstrual cycles variations with gut microbiota, and nowadays it is widely accepted that there are certain microorganisms directly implicated in the metabolism and effects mediated by estrogens and sex hormones, conforming what is designed as the estrobolome [361]

For example, AAV transduction of murine models of metallochaperone deficiency is a versatile approach and has been used to study truncated forms of ATP7B in a mouse model of Wilson disease

Rooseboom and Schaaf, 2002)

Additionally, other antiviral medications, such as molnupiravir and Paxlovid (combination of nirmatrelvir and ritonavir), were evaluated and authorized for emergency use in the treatment of COVID-19 [66,67,68]