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As electrons move down the ETC and eventually onto O 2 , released energy is used to create a proton gradient across the inner membrane, with a lower pH (higher proton concentration) and more positive charge (voltage gradient) in the intermembrane space than matrix

Research also shows that several environmental and lifestyle factors can increase the risk of macular degeneration, including smoking, a high-cholesterol diet, carotenoid status, vitamins A and E levels, zinc levels, age, sex, and exposure to heavy metal ions and other chemicals

doi: 10.1172/JCI19246 23 ShoelsonSEHerreroLNaazA

Providers should maintain a high index of suspicion for endometriosis in women with severe dysmenorrhea, particularly when symptoms are progressive or interfere with daily activities