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In addition, A53T and A30P -syn exhibit a stronger binding affinity for the lysosomal receptor LAMP2A compared with wild-type (WT) -syn, so these mutant forms of -syn are not efficiently degraded by protein clearance mechanisms, which results in increased -syn burden of chaperone-mediated autophagy and inhibits the loading and clearance of other cargo (Cuervo et al., 2004)

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Resources: The A to Z of EAI (Environmentally Acquired Illness) ISEAI About EAI International Society for Environmentally Acquired Illness (iseai.org) The Role of Mast Cells in the Defence against Pathogens PMC (nih.gov) Mast Cell: A Multi-Functional Master Cell PMC (nih.gov) Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options PMC (nih.gov) Mast Cell Activation Syndrome: Proposed Diagnostic Criteria PMC (nih.gov) Mast cell activation may explain many cases of chemical intolerance | Environmental Sciences Europe | Full Text (springeropen.com) Mast cell activation may explain many cases of chemical intolerance (mit.edu) * These statements have not been evaluated by the Food and Drug Administration

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