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Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)

In the rats that received GHK-Cu, the researchers found an increase in total protein and collagen synthesis greater than that of the placebo group, demonstrating that GHK-Cu is able to increase extracellular matrix accumulation in wounds in vivo .28 Are GHK-Cu copper peptides safe

Practical decision framing in the research-use community: if the research interest is structural repair, soft-tissue work, or skin remodeling alone, GLOW covers those bases

DOI: 10.1002/adbi.20230025 Feature image credit: Kenny Eliason on Unsplash