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Core keywords include dietary fiber, gut inflammation, depression, gut microbiota, short-chain fatty acids, omega-3 polyunsaturated fatty acids, vitamins, and minerals. Boolean operators (AND/OR) will be used to construct comprehensive search expressions, such as (dietary fiber OR resistant starch) AND (gut inflammation OR intestinal barrier) AND (depression OR mood disorder). Time period: studies published between January 2013 and December 2023 will be included to ensure the retrieval of the most recent evidence within the past decade

In vitro assays confirmed that Clc efficiently cleaved the immunogenic 33-mer peptide into three discrete fragments and hydrolysed a fluorogenic peptide containing the QPQL motif, highly resistant to GIT peptidases