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n acetylcysteine a safe antidote for cysteine glutathione deficiency N acetylcysteine: Impact on Psychiatric Disorders : Advances Glutathione Depletion Pathways 1. Precursor Depletion Key bottleneck: Cysteine availability. Source: Diet or hepatic transsulfuration (methionine homocysteine cysteine). Failure mode: Downregulation of cystathionine lyase (CSE) during Glutathione synthesis ScienceDirect Frontiers Case report: A Chinese patient with glutathione synthetase deficiency and a novel glutathione synthase mutation
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