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Although the underlying mechanisms of the gutheart axis during HF remain largely unknown, increased filling pressures and impaired diastolic blood pressure, which may lead to a progressive decrease in cardiac output, have been proposed as main drivers of gut ecological dysregulation (152)

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Comparative cost-effectiveness of surgery, collagenase Clostridium histolyticum, and penile traction therapy in men with Peyronies disease in an era of effective clinical treatment