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Ethics declarations Competing interests The authors declare no conflict of interest

Therefore, varying drugs, including antidiabetics, antioxidants, lipid-lowering drugs, probiotics, and anti-platelets, which might have potential beneficial effects, have been continuously investigated in patients with CLD [8-15]

doi: 10.1016/j.smim.2007.10.011 33 DuJHuangCZhouBZieglerSF

Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)