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The majority of polyphenols are anti-inflammatory by inhibiting the NF-B pathway, which is a master regulator of cytokine production ( in vitro and in experimental models of periodontitis, suggesting that polyphenols can modulate the host immune response towards a regenerative rather than a destructive phenotype ( Moreover, polyphenols possess antioxidant activity that resists the oxidative stress of periodontal inflammation

Vitamin B12 deficiency may occur in between 40% to 80% of the vegetarian population who are not also consuming a vitamin B12 supplement.In Hong Kong and India, vitamin B12 deficiency has been found in roughly 80% of the vegan population as well

doi: 10.1177/0271678X18764083 113

As research progresses, BCAA-metabolizing enzymes could potentially assist in tumor diagnosis and provide a theoretical basis for developing drugs that target these enzymes to inhibit tumor progression