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While these pathways have been extensively elucidated in cancer models, emerging evidence suggests that similar ROS-driven senescenceinflammation feedback loops may play a pathogenic role in chronic metabolic diseases such as T2DM, thereby amplifying tissue dysfunction and insulin resistance ( In recent years, microRNAs (miRNAs) have garnered significant attention for their regulatory roles in mitochondrial homeostasis and ROS scavenging, emerging as critical molecular bridges between mitochondrial dysfunction and insulin resistance