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Further analysis revealed that plasma L-Cn levels were positively correlated with serum levels of total bilirubin, direct bilirubin, and indirect bilirubin, but not with the serum albumin levels, creatinine concentration, and liver stiffness ( Figure 1D )

Utilities for quantifying separation in PCA/PLS-DA scores plots

the substitution of valine (V) with glutamic acid (E) (BRAF V600E) is the most common mutation, followed by the substitution of V with lysine (K) (BRAF V600K) (156)