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Conclusion: AB4 directly targets RAGE to inhibit the AGE/RAGE-Nrf2 axis, thereby suppressing both ferroptosis and inflammation in SALI

You can't supplement your way around a suppressed hypothalamic-pituitary axis

Because iron is indispensable for wrapping myelin and powering metabolic enzymes, oligodendrocytes outrank every other CNS cell population in intracellular iron content (Friedrich et al., 2021