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Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice

2018;28:92234.e4

291 Further research in 2021 revealed that copper induces the aggregation of p97-Npl4 by inhibiting ubiquitinated protein degradation, or directly binding to Npl4 and impeding its conformational changes, leading to cell death