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These findings suggest that endometrial organoids derived from AS patients have great potential as tools for investigating the pathobiology of the disease and that the organoid approach can be used for developing regenerative therapies aimed at restoring endometrial function

Cells were treated with or without 300 ng/ml doxycycline, 5 M A, 350 M buthionine sulfoximine (BSO), 5 M dimethyl fumarate (DMF), and 0.1 M ferrostatin-1 (Fer-1), as indicated