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6 Toxicity Study and Clinical Application of Chelerythrine 6.1 Toxicity and Security of Chelerythrine CHE has abundant pharmacological activity in the treatment of cancers but has been greatly restricted in clinical use because of its toxic side effects and other shortcomings

These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

Kuby Immunology

Our findings provide clues for potential drug development targeting the autophagic pathway for the treatment of COVID-19