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doi: 10.1038/s41593-019-0421-4 [DOI] [PubMed] [Google Scholar] 170.Periyasamy P, Liao K, Kook YH, Niu F, Callen SE, Guo ML, et al

Note that peptide bond, an amide bond, is strong and does not have free rotation around it because of the partial double bond character (see resonance structure)

Linking menopausal symptoms to progression of occlusive cardiovascular disease and/or hypertension and risk for adverse outcomes such as stroke, myocardial infarction or thrombosis is important as the current guidelines of the United States Food and Drug Administration (FDA) for use of hormonal treatment products is for relief of menopausal symptoms and not for prevention of chronic diseases

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