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LC/MS : C8-A (4.6 x 100 mm, 3 ) 1.5 mL min - 1 30 (0.1% TFA v/v) 10%-90% MeCN(0.1% TFA v/v) , 210 nm UV 3100 (ESI+ )

it is due to the effects of estrogenic metabolites of precursors from endogenous or exogenous sources, such as adrenal glands or therapeutic drugs