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These include the overexpression of enzymes involved in fatty acid metabolism, such as acyl-CoA synthetase long-chain family member 4 (ACSL4), antioxidant defense enzymes like glutathione peroxidase 4 (GPX4), transcription factors such as nuclear factor E2-related factor 2 (Nrf2), and plasma membrane repair molecules like the endosomal sorting complexes required for transport III (ESCRT-III) (Chen et al., 2021a)

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