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Melanotan II

Its cognition-enhancing effects may be due to an ability to influence the brains levels of noradrenaline, serotonin, and dopamine,4 three neurotransmitters with well-documented relationships to vigilance, attention, learning,5 memory,6 and the motivation toward cognitive effort.7 Meanwhile, its anxiolytic effects appear to be GABAergic (i.e., relating to the neurotransmitter GABA)

Denton R, Randle P, Martin B

Furthermore, prolotherapy (dextrose prolotherapy) requires a high level of clinical skill and vigilance to ensure accurate assessment, which may affect the consistency and reliability of outcome measurements across studies and must take into consideration specific etiological subtypes to better identify which patients are most likely to benefit from this intervention