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The results showed that fluorescence signals from all three suppository formulations were primarily detected within the colorectum over time, with only weak signals observed in major organs, including the heart, liver, spleen, lungs, kidneys, and small intestine

The global burden of ischemic heart disease is projected to rise dramatically, remaining the leading cause of cardiovascular death and accounting for a projected 20 million deaths by 2050 (Chong et al., 2025)

The underlying mechanism is as follows: in the presence of the terminal electron acceptor -oxygen- the electron transport chain maintains oxidation of NADH to NAD + by complex I, and this NAD + is supporting dehydrogenases, including the pyruvate dehydrogenase complex