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In addition to the regulation of 1 C metabolism, emerging evidence shows that enzymes in the one-carbon metabolic network also have important non-canonical functions, commonly referred to as moonlighting functions [5]

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis

When cultured murine skeletal muscle cells were atrophied by the pro-inflammatory cytokine TNF-, not only did trimetazidine significantly reverse the reduction in myotube size, it also increased myosin heavy chain expression and induced hypertrophy [160]

However, despite these promising results, further studies are needed to evaluate FMT in patients with psychiatric disorders, as this field entails several challenges regarding donors and recipients [55]