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MPH has been reported to modulate with pharmacological action three human protein targets (Table 1): it acts as an inhibitor of DAT (SLC6A3) [139] and NET (SLC6A2) [139] (both transporters of DA and NE, respectively), and as an agonist for the 5-hydroxytryptamine (serotonin) receptor 1A (HTR1A) [140, 141]

As mentioned earlier, mTORC1 promotes the translation of mitochondrial proteins encoded in nuclei, interestingly, using a genome-wide polysome profiling and translatome, it was demonstrated the treatment with rapamycin, PP242 and metformin (mTORC1 inhibitors) suppressed the translation of MTFP1 (99)

Vitiligo Vitiligo is an acquired depigmentation disorder characterized by distinct patches of skin where melanocytes, the pigment-producing cells, are destroyed due to autoimmune mechanisms 112

Plant glutathione biosynthesis revisited: Redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization