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Efficacy and safety of masitinib in progressive forms of multiple sclerosis: A randomized, phase 3, clinical trial

Therefore, by targeting the expression of the non-Smad signaling pathway RAS/rapidly accelerated fibrosarcoma (RAF)/FOXO signaling cascade and its downstream inflammatory factors TNF- and IL-1, AS-IV markedly inhibits the transdifferentiation of fibroblasts and alleviates LPS and cigarette smoke treatment-induced COPD-related EMT progression

This could limit the efficacy of nitrate supplementation, because RONS such as superoxide (O 2 -) directly react with NO, diminishing its bioavailability [85]