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doi: 10.3390/antiox8020051

Oxidative stress initiated by hypoxia and subsequent reoxygenation lead to lipid and protein oxidation and DNA degeneration 10,11

Lactate acidifies the microenvironment, thus promoting the secretion of pro-inflammatory cytokines [e.g., interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-] and inhibiting anti-inflammatory functions