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This enzyme is overactive in individuals with excess abdominal fat and metabolic dysfunction

Antigen presentation by these dendritic cells activates and drives renal T-cell infiltration with attendant renal pro-inflammatory cytokine release and altered renal histology (136, 137)

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Additionally, ROS are produced when TLR1, TLR2, and TLR4 stimulate the translocation of tumor necrosis factor receptor-associated factor 6 (TRAF6) into the mitochondria, promoting the degradation of the evolutionarily conserved signaling intermediate in the toll (ECSIT) protein (West et al., 2011)