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In saline-treated rats, Dox exposure caused sarcolemmal vacuolization, myofibrillar fragmentation, and extensive mitochondrial injury, including swelling, cristae disruption, and membrane dilation

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Results: Silencing of IGFBP7 in U937-derived M0 macrophages resulted in increased expression of genes associated with regenerative macrophages (e.g., MMP12, MMP13, IGF-1), while decreasing the expression of genes associated with inflammatory macrophages (e.g., TNF-)