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Statistical methods were not used to chose sample sizes

So, they dont need to be as efficient

Increased infiltration of TAMs is related to a more advanced stage and lymph node metastasis in CC ( + T-cell immunity by binding to PD-1, enabling CC immune escape ( Premetastatic niches Primary tumors can instruct the formation of microenvironments in distant organs hospitable to tumor cells before arriving at these sites

Notably, meta-omics (i.e., the combined application of metagenomics, metatranscriptomics, metaproteomics, and metabolomics to microbial communities) provides deep insights into microbiome-mediated immune signaling in pathologies such as colorectal cancer (174)