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Moreover, the combination of MSG and TA significantly mitigated the severe reduction in gene expression compared to MSG alone (Fig

The results described herein help to clarify the beneficial effects of melatonin against these conditions and define the potential clinical applicability of melatonin in cardiovascular diseases.

Namely, studies utilizing various MC-deficient mouse models have claimed that MCs are non-essential for the regulation of either CD4 + or CD8 + T cell immune responses (53, 54)