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Chiral selectivity underpins thousands of biological processes, including enzyme-substrate catalysis, redox reactions, signal transduction, control of amino acid synthesis and tRNA folding, ribosomal protein formation, nucleic acid identification, transcription and translation, metabolite interactions with cell signaling pathways, and other activities ( 2 Factors that catalyze chiral discrimination of 2-hydroxyglutarate Our primary focus in this review is the study of aberrant growth of 2-hydroxyglutarate (2HG) (C 5 H 8 O 5

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