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10.1016/s0166-2236(98)01299-5 14 DjakovicZ.DjakovicI.CesarecV.MadzaracG.BecejacT.ZukanovicG.et al (2016)

Indications: Overactive bladder Common symptoms include urgency, urinary incontinence, and increased urinary frequency Side Effects: increased blood pressure / hypertension urinary tract infections nasopharyngitis constipation Pharmacokinetics: taken orally by tablet, 25 mg once daily metabolized via multiple pathways involving dealkylation, oxidation, glucuronidation, and hydrolysis 6-12% is eliminated unchanged by the kidney, involving glomerular filtration and active secretion that is dose-dependent Drug Interactions: mirabegron is a moderate inhibitor of CYP2D6 Notes: the estimated Walmart cost for Mybetriq oral 50mg tablets is ~$440 for a supply of 30 tablets (GoodRx.com

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Circulation 104(22):26732678 Van Thiel DH, Tarter R, Gavaler JS, Schade RR, Sanghvi A (1986) Thyroid and pituitary hormone responses to TRH in advanced nonalcoholic liver disease