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Microenvironmental cues promoting the DTP phenotype Several studies have shown that the acidic, hypoxic and nutrient-depleted tumour niche favours the emergence of DTPs (reviewed elsewhere 146 )

Despite these divergent pathways, both sexes converged on the same endpoint: a desperate, compensatory upregulation of intracellular glutathione in immune cells that ultimately drains the hosts systemic energy

doi: 10.1038/nrn2038

Moreover, mitochondrial morphology of SLC27A5-overexpressing HCC cells manifested as decreased even vanished mitochondria cristae, and increased mitochondrial membrane density compared to the control group (Fig