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Membrane lipid alterations as a possible basis for melanocyte degeneration in vitiligo

Although numerous topical and systemic therapeutic agents and also non-pharmacologic procedural treatments have been considered in melasma management, however, the commonly available therapeutic options have several limitations including the lack of sufficient clinical effectiveness, risk of relapse, and high rate of unwanted adverse drug reactions

It demonstrates no tolerance development meaning effectiveness doesnt diminish over time, no rebound insomnia upon discontinuation, and no dependency issues

Liu H, Liu J, Xu E, Tu G, Guo M, Liang S, et al