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Understanding the early pathological changes that precede Lewy body pathology (LBP) and cell loss in PD will likely support the identification of novel diagnostic and therapeutic strategies and help to differentiate LBP-dependent and -independent alterations

For example, targeting HIF transcription factors (involved in ROS production pathways) has been shown to improve outcomes in patients with hematopoietic disorders by reconstructing the niche composition

Cell diversity and network dynamics in photosensitive human brain organoids