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Furthermore, the ethical constraints of testing novel therapies in pregnant populations, given potential fetal harm, limit the available translational pathways, exacerbating the gap between preclinical promise and clinical application [68]

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Immunohistochemistry of brain tissues from mice treated with GHK showed evidence of decreased inflammation and increased labeling of histone deacetylase 2, suggesting that in addition to an anti-inflammatory effect, GHK may be triggering an epigenetic pathway in the amelioration of cognitive impairment in aging mice

An 8-week cycle might follow this pattern: 2 weeks introduction, 4 weeks optimization, 2 weeks maintenance