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As guidance, please look at some suggestions present in our IP protocol

Loss of efficacy

Summer 2007;15(2):77-82

LF treatment significantly down-regulated the high-salt and high-fat-induced renal NLRP3 inflammatory vesicles and protein expression levels of inflammatory factors and regulated the expression levels of mRNAs related to the renin-angiotensin-aldosterone system pathway, which can prevent 8% NaCl diet-induced hypertension and renal injury in mice ( Hypotensive peptides derived from lactoferrin have also been identified, and the angiotensin-converting enzyme-inhibiting tripeptide low-density lipoprotein receptor related protein (LRP) derived from bovine lactoferrin, has antihypertensive effects ( in vitro antihypertensive effect