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Ferroptosis is associated with the inactivation of cellular antioxidant systems, especially system Xc - , which causes the accumulation of lipid peroxides ( - is an amino acid counter-transport protein widely distributed in phospholipid bilayers and consists of two independent proteins: solute carrier family 7 member 11 (SLC 7 A 11 ) and solute carrier family 3 member 2 (SLC 3 A 2 ) ( 4 is a key regulator of ferroptosis and inhibits ferroptosis by inhibiting the production of lipid peroxides

As placental growth is associated with its blood perfusion 44 , we speculate whether decreased estradiol observed in the present study is associated with decreased placental perfusion/growth and fetal growth