6.3.1 Efficacy signals Human studies of canonical MFH-relevant polyphenols (e.g., curcumin, EGCG) remain small and methodologically limited
In wild-type mice, Cx32 abundance in hepatocytes decreased substantially as early as 1-h post-APAP treatment, reaching a 20% reduction compared to the steady-state or control group
TBS detects specific changes in bone quality related to trabecular microarchitecture, improving the diagnosis of the high risk of fragility fractures
Abbreviations 3-MA: 3-Methyladenine ADSC: Adipose-derived stem cell DEG: Differentially expressed gene ROS: Reactive oxygen species LPOs: Lipid peroxides OGD: Oxygen and glucose deprivation MDA: Malondialdehyde SOD: Superoxide dismutase Fer-1: Ferrostatin-1 GSH: Glutathione H&E: Hematoxylin and eosin KEGG: Kyoto Encyclopedia of Genes and Genomes MRI: Magnetic resonance imaging NAC: N -Acetylcysteine Nec-1: Necrostatin-1 NS: Normal saline PBS: Phosphate-buffered saline qRT-PCR: Quantitative real-time polymerase chain reaction SD: Standard deviation TEM: Transmission electron microscopy References Smith P, Adams WP Jr, Lipschitz AH, Chau B, Sorokin E, Rohrich RJ, Brown SA