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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations TMAU, trimethylaminuria

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If the absorption of L-carnitine through the diet is not sufficient or there is an increased need, or the bodys own synthesis is reduced, this nutrient can be supplemented through special food supplements

We thank Qin Deng and Guocan Zheng in Analytic and Testing Center of Chongqing University for use of the facility and technical support for confocal and GCMS/MS analysis, ShanghaiTech School of Life Science and Technology Core facility, and Ying Han for their assistance with sphingolipid profiling and quantification, and Yu Kong and Lijun Pan (Electron Microscopy Facilities of Center for Excellence in Brain Science and Technology, CAS) for assistance with EM sample preparation and EM image analysis