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That was the question posed by experts from the University of Medicine and Dentistry of New Jersey in a 2008 review paper

82 Lack of phosphatidylethanolamine (PE) methylation leads to the SAM accumulation, which results in hypermethylation of histones and the major phosphatase PP2A, dependency on cysteine, and sensitivity to oxidative stress

[8] Structural organization in eukaryotes and prokaryotes In eukaryotes , particularly in mammals, Drosophila , and Dictyostelium (a genus of amoebae), these three enzymatic activities are located on a single polypeptide chain, encoded by a gene derived from a gene fusion event that occurred at least 100 million years ago