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In phase 3 trials, lecanemab and donanemab slowed clinical decline in early Alzheimers by roughly a quarter to a third over eighteen months, with a known risk of amyloid-related brain swelling and small bleeds

PMID: 31067138

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Baseline Oxidative Stress Individuals with high baseline oxidative stress smokers, heavy alcohol consumers, chronic disease patients, endurance athletes typically report more dramatic improvements because the deficit being corrected is larger