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These findings emphasize the potential interplay between intestinal inflammation and the development of RA, shedding light on the systemic nature of this disease

A separate 2025 narrative review confirmed three total published human pilot studies and noted that no major adverse events were reported across those pilots [15]

In the context of longevity medicine, it is used as a periodic cellular reset rather than as a continuous therapy

N -(5-(((5-( tert -butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)thio)butyl)piperidine-4-carboxamide ( 25 )