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In addition to the common clinical manifestations shared with CCDS1, CCDS2 is characterized by specific behavioral disorders, including autistic behavior and self-mutilation [39]

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Furthermore, as trauma is undoubtedly at the origin of PD and even micro-injuries may bear serious consequences in genetically predisposed patients, even injections must be considered a source of microtrauma for the tissues, therefore we made sure to use a very thin needle when performing the injections in the area around the plaque, and we decreased the number of injections at every treatment cycle