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It was first isolated and characterised by Professor Predrag Sikiric and his research group at the University of Zagreb in the early 1990s, with the foundational paper published in the Journal of Physiology (Paris) in 1993

If I had a patient come in with a headache and she cracks an egg over her head every time to help the headache and she says it feels better, Im not going to stop her

The signaling pathway mediated by the MAP-kinases ERK1 and ERK2 plays an essential role in the control of cell proliferation, differentiation, and survival in physiological conditions, and so failures associated with regulation of this pathway significantly contribute to cell transformation, and these are undoubtedly involved in tumor progression (Fig