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ET-1, exclusively expressed in endothelial cells, enhances the oxidative modification of LDL via the ETB receptor, which further increases the uptake of oxLDL in endothelial cells via the LOX-1 receptor leading to the progression of atherosclerosis (20)

Moreover, a few cases of intentional high-dose ALA overdose have resulted in significant harm, including liver failure and, in one adolescent, a fatal outcome

Because of this, it has been hypothesized that supplementation of ASL antioxidants through diet or inhalation could bolster antioxidant defenses and mitigate air-pollution induced oxidative stress

Imaging 7 (6), 7290.2008.00025262